NIMG-24. LONGITUDINAL MR SPECTROSCOPY TO DETECT PROGRESSION IN PATIENTS WITH LOWER-GRADE GLIOMA IN THE SURVEILLANCE PHASE

Abstract BACKGROUND Monitoring lower-grade gliomas (LrGGs) for disease progression is made difficult by the limits of anatomical MRI to distinguish treatment-related tissue changes from tumor progression. MR spectroscopic imaging (MRSI) offers additional metabolic information that can help address these challenges. The goal this study was compare longitudinal in multiparametric MRI, including diffusion-weighted imaging, perfusion and 3D MRSI, LrGG patients who progressed at final time point those remained clinically stable. METHODS Forty-one with were stable longitudinally assessed Changes anatomical, diffusion, perfusion, MRSI data acquired compared between progressed. RESULTS Thirty-one stable, 10 Over period, had a significantly greater increase normalized choline, choline-to-N-acetylaspartic acid index (CNI), creatine, creatine-to-N-acetylaspartic (CRNI), than patients. CRNI associated status WHO type. Progressed astrocytoma increases CONCLUSIONS surveillance tumors increasing choline creatine metabolite signals on trend T2 FLAIR volumes, These show be used conjunction studies gain clearer picture progression, especially setting clinical ambiguity.